Protection from experimental colitis by theaflavin-3,3′-digallate correlates with inhibition of IKK and NF-κ B activation

Molluscum Contagiosum Virus protein MC 005 inhibits NF κ B activation by targeting 1 NEMO - regulated IKK activation

Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-digallate (TF3)

SARS-CoV is the causative agent of severe acute respiratory syndrome (SARS). The virally encoded 3C-like protease (3CL(Pro)) has been presumed critical for the viral replication of SARS-CoV in infected host cells. In this study, we screened a natural product library consisting of 720 compounds for inhibitory activity against 3CL(Pro). Two compounds in the library were found to be inhibitive: ta...

TAFII 105 mediates activation of anti - apoptotic genes by NF - κ B

The transcription factor NF-κB is important for expression of genes involved in immune responses, viral infections, cytokine signaling and stress. In addition NF-κB plays a crucial role in protecting cells from TNFα-induced apoptotic stimuli, presumably by activating anti-apoptotic genes. Here we report that the substoichiometric TFIID subunit TAFII105 is essential for activation of anti-apopto...

Radiation - induced activation of NF - κ B involves the selective degradation of plasma membrane - associated I κ B α

Radiation-induced activation of NF-κ κ κ κB involves the selective degradation of plasma membrane-associated Iκ κ κ κBα α α α ABSTRACT In contrast to NF-κB activation by TNF-α, the specific processes involved in the activation of this transcription factor by ionizing radiation (IR) have not been completely defined. According to the classical paradigm, a critical event in NF-κB activation is the...

Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation.

NF-κB, which is activated by the inhibitor of NF-κB kinase (IKK), is involved in the progression of inflammatory disease. However, the effect of IKK inhibition on the progression of myocarditis is unknown. We examined the effect of IKK inhibition on the progression of myocarditis. Lewis rats were immunized with porcine cardiac myosin to induce experimental autoimmune myocarditis (EAM). We admin...